D-thyroxine (Levaxine®) has not given any symptomatic relief in Dercum’s disease. This further supports that the thyroid gland is not involved in the pathogenesis of the disease.

Fagher B, Monti M, Nilsson-Ehle P, Akesson B: Fat-cell heat production, adipose tissue fatty acids, lipoprotein lipase activity and plasma lipoproteins in adiposis dolorosa. Clin Sci (Lond) 1991, 81:793–798.


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