Calcium-channel modulators

Several calcium-channel modulators have been tried; for instance, pregabalin (Lyrica®) (anticonvulsant) [1] and oxacarbazepine (Trileptal®) (anticonvulsant) [2-4]. Calcium-channel modulators inhibit the activation of neuronal calcium channels and thereby inhibit the release of substances, such as excitatory amino acids, that are necessary for central sensitisation. These drugs are used to treat neuropathic pain [5]. Several of these substances have a broad range of pharmacological actions and other mechanisms beyond calcium-channel modulation that might contribute to their effectiveness in treating neuropathic pain [5].

1. Lange U, Oelzner P, Uhlemann C: Dercum’s disease (Lipomatosis dolorosa): successful therapy with pregabalin and manual lymphatic drainage and a current overview. Rheumatol Int 2008, 29:17–22.
2. Tiesmeier J, Warnecke H, Schuppert F: An uncommon cause of recurrent abdominal pain in a 63-year-old obese woman. Dtsch Med Wochenschr 2006, 131:434–437.
3. Campen RB, Sang CN, Duncan LM: Case records of the Massachusetts General Hospital. Case 25–2006. A 41-year-old woman with painful subcutaneous nodules. N Engl J Med 2006, 355:714–722.
4. Pardal Refoyo JL: Adiposis dolorosa (Dercum’s disease). An Otorrinolaringol Ibero Am 1996, 23:435–440.
5. Baron R: Neuropathic pain: a clinical perspective. Handb Exp Pharmacol 2009, 194:3–30.

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