Methotrexate and Infliximab
One patient’s symptoms were improved with methotrexate and infliximab. However, in another patient with Dercum’s disease, the effect of methotrexate was discreet. The mechanism of action is unclear. Methotrexate has been shown to reduce neuropathic pain caused by peripheral nerve injury in a study on rats .
1. Singal A, Janiga JJ, Bossenbroek NM, Lim HW: Dercum’s disease (adiposis dolorosa): a report of improvement with infliximab and methotrexate. J Eur Acad Dermatol Venereol 2007, 21:717.
2. Moi L, Canu C, Pirari P, Mura MN, Piludu G, Del Giacco GS: Dercum’s disease: a case report. Ann Ital Med Int 2005, 20:187–191.
3. Scholz J, Abele A, Marian C, Haussler A, Herbert TA, Woolf CJ, Tegeder I: Low-dose methotrexate reduces peripheral nerve injury-evoked spinal microglial activation and neuropathic pain behavior in rats. Pain 2008, 138:130–142.
*Case reports are generally considered a type of anecdotal evidence. Given their intrinsic methodological limitations, including lack of statistical sampling, case reports are placed at the foot of the hierarchy of clinical evidence, together with case series. https://en.wikipedia.org/wiki/Case_report