Analgesics

The pain in Dercum’s disease is often reported to be refractory to analgesics and to non-steroidal antiinflammatory drugs (NSAIDs) [1-11]. However, this has been contradicted by the findings of Herbst et al. [12]. They reported that the pain diminished in 89% of patients (n=89) when treated with NSAIDs and in 97% of patients when treated with narcotic analgesics (n=37).  The dosage required and the duration of the pain relief are not precisely stated in the article.

1.Eisman J, Swezey RL: Juxta-articular adiposis dolorosa: what is it? Report of 2 cases. Ann Rheum Dis 1979, 38:479–482.  2.Taniguchi A, Okuda H, Mishima Y, Nagata I, Oseko F, Hara M, Otsu A, Kataoka K, Kono T, Imura H: A case of adiposis dolorosa: lipid metabolism and hormone secretion. Int J Obes 1986, 10:277–281.  3.Amine B, Leguilchard F, Benhamou CL: Dercum’s disease (adiposis dolorosa): a new case-report. Joint Bone Spine 2004, 71:147–149.  4.Nahir AM, Schapira D, Scharf Y: Juxta-articular adiposis dolorosa–a neglected disease. Isr J Med Sci 1983, 19:858–859.  5.Atkinson RL: Intravenous lidocaine for the treatment of intractable pain of adiposis dolorosa. Int J Obes 1982, 6:351–357.  6.Brodovsky S, Westreich M, Leibowitz A, Schwartz Y: Adiposis dolorosa (Dercum’s disease): 10-year follow-up. Ann Plast Surg 1994, 33:664–668.  7.Chopra A, Walia P, Chopra D, Jassal: Adiposis dolorosa. Indian J Dermatol Venerol Leprol 2000, 66:101–102.  8.De Silva M, Earley MJ: Liposuction in the treatment of juxta-articular adiposis dolorosa. Ann Rheum Dis 1990, 49:403–404. 9.George R, Poonnoose P, Isaiah R: Dercum’s disease (Adiposis dolorosa): delayed diagnosis in a patient with cervical cancer. J Palliat Care 2004, 20:324–325.  10.Juhlin L: Long-standing pain relief of adiposis dolorosa (Dercum’s disease) after intravenous infusion of lidocaine. J Am Acad Dermatol 1986, 15:383–385. 11.Scheinberg MA, Diniz R, Diamant J: Improvement of juxtaarticular adiposis dolorosa by fat suction. Arthritis Rheum 1987, 30:1436–1437.  12.Herbst KL, Asare-Bediako S: Adiposis dolorosa is more than painful fat. The Endocrinologist 2007, 17:326–334.

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