Adipose Tissue Dysfunction

It has been proposed that Dercum’s disease is a local defect in lipid metabolism [1]. An investigation [1] of fatty acid biosynthesis in two patients with Dercum’s disease suggested that there might be a deficit in the formation of monounsaturated fatty acids in subjects affected by the disease. However, contradictory findings were revealed in another study, comprised of 13 patients with Dercum’s disease [2]. 

Regarding adipose tissue function in Dercum’s disease, the findings are inconclusive[3].

1.http://www.lipidworld.com/content/11/1/19
2.http://www.ncbi.nlm.nih.gov/pubmed/4105769
3.http://www.ojrd.com/content/pdf/1750-1172-7-23.pdf

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