Adipose Tissue Dysfunction
It has been proposed that Dercum’s disease is a local defect in lipid metabolism . An investigation  of fatty acid biosynthesis in two patients with Dercum’s disease suggested that there might be a deficit in the formation of monounsaturated fatty acids in subjects affected by the disease. However, contradictory findings were revealed in another study, comprised of 13 patients with Dercum’s disease .
Regarding adipose tissue function in Dercum’s disease, the findings are inconclusive.