Nerve Compression

Pain & weakness from Dercum’s Disease (adiposis dolorosa) is  often attributed to lipomas (fatty deposits) applying pressure to nerves.  This explanation is included in many definitions of the disease [1,2,3].  This theory has not been confirmed histopathologically in patients with Dercum’s Disease[4]. However, nerve compression secondary to adjacent lipomas is a recognized medical condition[5,6,7]. Most lipomas are asymptomatic, but they can cause pain when they compress nerves[8]. In fact, neuropathic pain related to subcutaneous lipoma without direct nerve compression is possible[9]. Lipomas exhibit a different cytokine profile than normal adipose, which may contribute to neural inflammation or microvascular changes[9].

1.http://misc.medscape.com/pi/android/medscapeapp/html/A1082083-business.html 
2.http://www.emergingworlds.com/ch_conditions_detail.cfm?vPageid=157 
3. http://www.genome.gov/17516629 
4.http://www.ojrd.com/content/pdf/1750-1172-7-23.pdf 
5.http://www.ncbi.nlm.nih.gov/pubmed/17320633 
6.http://www.med.nyu.edu/neurosurgery/pns/conditions/tumors/lipomas.html 
7.http://scholar.google.com/scholar?hl=en&q=lipoma+nerve+compression&btnG=&as_sdt=1%2C18&as_sdtp= 
8.http://www.patient.co.uk/doctor/Lipoma.htm
9. http://www.painmed.org/library/posters/poster-261/

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