Lipomatosen

This document is in German. Google Translate was used on the following paragraphs.

In the case of lipomatosis dolorosa, generalized and diffuse painful subcutaneous adipose tissue tumors occur. Mainly obese women are affected; the incidence peak is between the ages of 35 and 50, often after the menopause. The rare disease was in the year First described in 1892 by Francis Xavier Dercum, an American doctor. More detailed data on epidemiology are not yet available, so that the current literature is limited to individual cases and smaller case series.

The previously suspected endocrine or neuronal dysfunctions did not stand up to review in studies. Likewise, no clear evidence of disturbances in fatty acid metabolism or an increased “level of inflammation” was found. There were no significant differences in the concentration of tumor necrosis factor (TNF) -α, interleukin (IL) in ten patients with Dercum disease compared to an age, BMI, body fat mass and weight-adjusted female control cohort. 1β, IL-8, IL-10, CC chemokine ligand (CCL) 3, leptin or adiponectin. Even the earlier hypothesis that the genesis is traumatically induced can not be substantiated by the few case reports published in this regard.
In a study from 2014 with indocyanine green visualization of the lymphoid pathways by near infraRed fluorescence (NIRF) videography in three patients with Dercum disease, delayed lymphatic drainage was detected in the dilated lymphatics of the lipomas. The mutation of mitochondrial DNA described in BSL has not been proven in Dercum disease.

Full text PDF here: https://onlinelibrary.wiley.com/doi/abs/10.1111/ddg.13460_g

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