Author Archive: ddresearch1

Infections Preceding the Development of Dercum disease

This case series calls attention to the presence of lipomas occurring after infections including Lyme disease, histoplasmosis and coccidioidomycosis. Studies examining larger populations with infections are needed, and evaluation of adipose tissue and the lymphatic system in animal models of infections may provide evidence further connecting infection and changes in fat tissue consistent with lipomas. …

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Adiposis Dolorosa Pain Management

Current therapeutic approaches to AD focus on invasive surgical intervention, chronic opiate and oral medication management. However, we have detailed several additional approaches to AD treatment. Ketamine infusions, which have long been a treatment in other chronic pain syndromes may present a viable alternative to lidocaine infusions in patients with AD. Electrocutaneous stimulation is a …

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Identification of somatic alterations in lipoma using whole exome sequencing

Until now, reason for lipoma occurrence not been identified. We performed whole exome sequencing to define the mutational spectrum in ten lipoma patients along with their matching control samples. We presented genomic insight into the development of lipomas, the most common benign tumor of soft tissue. Our analysis identified 412 somatic variants including missense mutations, …

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Genetic syndromes with localized subcutaneous fat tissue accumulation

Summary. Syndromes with localized accumulation of subcutaneous fatty tissue belong to a group of genetically and phenotypically heterogeneous disorders. These diseases may show some common signs, such as nodular fat, symmetrical fat masses, obesity, fatigue, lymphedema and symmetrical lipomas (painful or otherwise). Other symptoms may be specific for the different clinical entities, enabling correct differential …

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Localized Nodular Adiposis Dolorosa – Case Study

A 58-year-old female with no previous medical history presented with a 10-year history of recurrent bilateral metacarpophalangeal and proximal interphalangeal joint pain and inflammation, associated with morning stiffness. Early in the course of her disease, she presented to a primary care clinic but did not followed-up due to economic reasons. At the time of this …

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