The numbers studied were relatively small, particularly relating to Dercum’s disease. Findings were limited by retrospective evaluations, use of poorly validated tools and relatively short follow-up periods in some studies. There were no randomised clinical trials. Lack of standardisation made it challenging to analyse and compare outcomes across different studies. Liposuction appears to play a role as a treatment option for some women in managing symptoms. However, further research is required to better explore efficacy and cost-effectiveness, monitor adverse effects, inform decision making and identify key advice for women who undergo liposuction.
Question-based Self-reported Experience of Patients with Subcutaneous Adipose Tissue (SAT) Disease Prescribed Sympathomimetic Amines
People with lipedema and DD report a significant benefit to risk ratio for their fat, pain and quality of life when prescribed sympathomimetic amines. A randomized prospective study would confirm benefits, safety and side effects.
Lipedema is an uncommon disorder characterized by localized adiposity of the lower extremities, often occurring in females with a family history of this condition. It is described as “adiposis dolorosa” or painful fat and is related to the more extreme adipose tissue disorder, Dercum’s disease.
This is a case study suggesting lipedema with associated morbid obesity as a possible risk factor for arterial thrombosis. There are no similar cases reported in literature, and further research may throw some light on this rare entity. Thus, early recognition of lipedema by its clinical manifestations is necessary to prevent complications such as ischemia.
Full Text: Mutnal S, Rangappa P, Jacob I, Chaitanya K, Rao K. A case report of lipedema with acute bilateral lower limb ischemia. Indian J Vasc Endovasc Surg [serial online] 2019 [cited 2019 Jun 11];6:132-4. Available from: http://www.indjvascsurg.org/text.asp?2019/6/2/132/25965
Abstract – Dercum’s disease is a rare disease, which mainly affects women and has an unknown prevalence and aetiology. The disease is characterised by generalised obesity and more than three-month painful subcutaneous adipose tissue not responding to usual pain treatment. A suggested classification of the disease includes four types: generalised diffuse, generalised nodular, localised nodular and juxta-articular. Diagnosis is one of exclusion, and treatment includes medical and surgical options with the aim of pain palliation and increased mobility and function.
Full text at journal site
Article in Danish.
Novel Use of Deoxycholic Acid for Adiposis Dolorosa (Dercum Disease).